Most clinical trials and surveys published over at least 20 years show that SLIT is relatively safe and effective for the treatment of rhinitis and asthma caused by allergies to dust mites, grass, ragweed, cat dander, and tree pollens. As of June 2009, of 60 double-blind, placebo-controlled studies of SLIT, 48 trials showed positive results and 12 showed results that were totally or almost totally negative, according to the WAO paper. Evidence is emerging that SLIT may be effective for treating the red, itchy eyes caused by pollen during hay fever season.
It also might prove an effective therapy for children with mild atopic dermatitis (eczema) and is currently being studied for its potential in treating food allergies.
Side effects among both children and adults are usually local and mild, most often occur early in treatment, and include itching in the mouth or stomach problems. These can usually be managed by dose adjustments. International studies reveal that SLIT can be safe for children younger than 5 and may be a preferred method for controlling allergy symptoms compared with injection therapy. Very rarely, severe allergic reactions (anaphylaxis) have been reported using SLIT. Therefore, this treatment is best prescribed by an allergist.
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