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What causes autoimmune disease?


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Autoimmune diseases usually do not usually have a simple, single cause.  There are usually two major factors that are involved in causing them: genetics and environment.  
Genetics - Even with a genetic connection to autoimmune disease, there is no guarantee that you will develop an autoimmune disease.  Something must "turn on" your immune system to trigger an autoimmune response.
Environment - Environmental factors make up more than half the risk of developing an autoimmune disease.  We know that certain environmental substances can trigger autoimmune disease.  For example, silica can trigger scleroderma; certain drugs can trigger lupus; and, in some women, pregnancy can trigger an autoimmune disease

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