Obviously, the best way to get a negative drug test is not take drugs, including Vicodin, unless it was specifically prescribed for you for a medical condition. In this case, disclose that you are taking it and why.
Vicodin or hydrocodone can remain in your system for four days or even longer, depending on your dosage and ability to clear it and of course, the sensitivity of the laboratory testing (they are getting better and better). A urine drug screen should be fine after about a week if you want a margin of safety. If they do a hair analysis, opiates can be detected for months.
The goal of a drug screen is to make sure you are not taking drugs that could interfere with your safety or the safety of others, so if you are taking Vicodin that has not been prescribed to you, or taking it recreationally, you need to re-evaluate this dangerous practice.
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