I was on Singulair for about 15 years without any effects to my liver. My normal yearly physical exams include blood work and my liver numbers were always in the normal range. In the summer of 2012, my insurance decided to change my Singulair prescription to Montelukast because it's cheaper (how nice of them!). Everyone said it's the same exact thing as Singulair, but for some reason I was apprehensive and just didn't trust this new medicine.
In February 2013, I had my yearly physical and my liver numbers had sky rocketed way beyond the normal ranges (they look at 2 numbers, AST and ALT). Even though I'm not a heavy drinker, the doctor had me stop all alcohol for 6 weeks and then I was retested. The results were exactly the same as before so alcohol wasn't the culprit. The doctor wanted to send me to the hospital for additional tests, including to check for hepatitis, to see why I was exhibiting liver damage. I asked if I could try fasting from Montelukast for 6 weeks first before undergoing a bunch of other tests and the doctor agreed because he said I wasn't in danger. However, he didn't think Montelukast was the cause.
I had a feeling it was Montelukast because nothing else had changed in the last few years other than that. After 6 weeks of not taking Montelukast, I was retested and my liver numbers dropped by HALF! My AST was back in the normal range and my ALT was just above the high normal which is nothing to worry about. Therefore, I was right, it was the Montelukast that was causing my liver damage. This medication may be cheaper, but it's more detrimental to me physically and isn't worth the savings to me.
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