Current manufacturing processes for flu vaccines include growing influenza virus in chicken eggs. For this reason, the finished vaccine contains a trace amount of egg protein. This trace amount of egg protein could cause a reaction in certain susceptible people. However, several recent studies have documented safe receipt of TIV (flu shot) in people with egg allergy, particularly those with a history of less severe reactions to egg. The current recommendation is that people with mild reactions to egg — specifically, those who have only experienced hives — can get flu vaccine, but they should get it with some additional safety measures, including observing the person for 30 minutes after vaccination. These people should receive TIV rather than the nasal spray vaccine. Also, people who have severe reactions to egg should be referred to a health care professional with expertise in the management of allergic conditions for further risk assessment before being vaccinated.
Detailed recommendations for vaccination of persons with egg allergy can be found at: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6132a3.htm?s_cid=mm6132a3
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