Sublingual immunotherapy is an alternative way to treat allergies without injections. An allergist gives a patient small doses of an allergen under the tongue to boost tolerance to the substance and reduce symptoms. According to a 2009 World Allergy Organization (WAO) paper, SLIT is widely accepted and used in European, South American, and Asian countries as well as in Australia and is gaining interest from allergists in the United States. However, as neither the safety nor the efficacy of the procedure is as yet considered established by the FDA, SLIT is not approved in the United States and its usage is off-label. However, trials for FDA registration are ongoing, with aspects of therapy including best dose and treatment duration, lasting effect, and the exact way SLIT works are all under investigation.
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