K-2, or spice, is marketed as an herbal substance. It can either be used as incense or smoked, and it remains legal in the United States. The product contains synthetic compounds (psychoactive substances) similar to THC. The psychoactive substances in K-2 bind very strongly to the CB-1 receptors in the brain but not so strongly to the CB-2 receptors, resulting in very accuentuated psychoactive effects. If a person would use this substance on a regular basis, then cumulative effects on the CB-l brain receptors could explain a personality change.
So far, serious drug reactions such as seratonin syndrome have not been reported, but K-2 abuse is on the rise.
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