Yes, you can, but very few people do.
Mononucleosis is usually caused by the Epstein-Barr virus (EBV). Symptoms usually include fever, swollen and painful tonsils, and enlarged lymph nodes. Fatigue and low energy can last for weeks or months. More than 90% of us eventually catch EBV, usually during adolescence or early adulthood. In many people, the illness is mild, and may never be diagnosed as mono. Infection by EBV generally results in lifelong immunity—you can only have EBV mono once.
There’s also a less common form of mononucleosis, caused by infection by cytomegalovirus (CMV). In one study of people with mono, about one out of seven had mono caused by CMV; the rest had typical EBV mononucleosis. Catching and recovering from EBV mono offers no protection against CMV mono, and vice versa.
Few people get mono from CMV. Most people are infected with CMV at some point in life, and experience only mild, short-lived symptoms. After that, they are generally immune to CMV mono or other illnesses caused by CMV.
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