Associate Clinical Professor, St. John's University College of Pharmacy and Health Sciences
314 Answers 6,370 Helpful Votes 25 Followers
Both amitriptyline and diphenhydramine can cause side effects such as drowsiness, dry mouth, and constipation. If you take them together you may notice more intense side effects. Other than that, they are safe to use together for most people.
If you notice side effects that are very bothersome or severe, you should talk to your health-care professional.
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