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Q.

Can medicines cause sun sensitivity?

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Heather Free, PharmDHeather Free, , PharmD
Heather Free, PharmD
Pharmacology
American Pharmacists Association
A.

There are several medications that can lead to photosensitivity, or sun sensitivity. Photosensitivity appears similar to sunburn and usually occurs within 24 hours of exposure to the sun while taking photosensitivity medications.

Avoiding sun exposure and tanning beds is recommended for protection while using these medications. Apply sunscreen SPF 30 or higher with UVA and UVB protection every few hours if you will be exposed to the sunlight. Some common medications that can lead to photosensitivity include, but are not limited to:

  • Antibiotics: ciprofloxacin, levofloxacin, tetracycline, doxycycline, minocycline, TMP-SMX.
  • Antihistamines: diphenhydramine.
  • Antidepressants: amytriptyline, desipramine, doxepin, imipramine, nortriptyline, trazodone.
  • Malaria medications: quinine, chloroqine, hydroxychloroquine.
  • Chemotherapy medications: 5-fluorouracil, vinblastine, dacarbazine.
  • Disease-modifying agents (rheumatoid arthritis/lupus): dapsone, hydroxychloroquine, methotrexate, sulfasalazine.
  • Cardiac/blood pressure medication: amiodarone, nifedipine, quinidine, diltiazem, furosemide, hydrochlorothiazide.
  • Diabetic medications: chlorpropamide, glyburide.
  • Nonsteroidal anti-inflammatory medications: naproxen, piroxicam, ibuprofen.
  • Acne medications: isotretinoin (Accutane).
  • Oral contraceptives.

Before taking your medications or spending time in the sun, consult your pharmacist to find out if your medication(s) can lead to photosensitivity.

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