Is it true that Clomid should never be given to someone with endometriosis?

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Is it true that Clomid should never be given to someone with endometriosis?

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David K. Walmer, MD, PhD

Reproductive Endocrinology

Duke Medicine

8 Answers
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Endometriosis refers to the presence of uterine lining tissue living outside of the uterine cavity. It can be associated with pain, adhesions, infertility, bladder or bowel symptoms, etc. or none of the above. One of the key words to describe endometriosis is 'unpredictable'. It may respond to one medication today and not tomorrow. The treatment depends on a patients goals, resources, history, etc.

...Clomiphene citrate [Clomid] is in the family of medications called selective estrogen receptor modulators. It is a very weak estrogen in many estrogen-responsive tissues. That means that Clomid can block or reduce the body's response to natural estrogen. Since natural estrogen causes the lining of the uterus to grow, potent estrogens may also cause endometriosis implants to grow as well. In the sense that Clomid would blunt this response; we would not expect Clomid to make endometriosis worse if we are using it to treat a patient with infertility.

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