WebMD Answers
If you’re wearing pajamas, changing sheets once a week is fine. If you’re not wearing pajamas or sleeping in the nude then you’ll probably want to be changing them at least twice a week. A lot of people when they change their sheets, they don’t wash their mattress pad, and so that’s another thing that people do. You need to have a couple of mattress pads that you can rotate in and out and change more often.
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