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The main feature of scleroderma is excessive production of collagen. Collagen is one of the building blocks from which skin is made. When too much collagen accumulates, it causes various tissues to become thick and lose flexibility and affects their ability to perform their function.

The underlying cause of scleroderma remains unclear. For some unknown reason, the immune system turns against the body and results in the overproduction of collagen. Current research focuses on the interplay between the immune system, the vascular (blood vessel) system, and the growth of connective tissue. Studies with twins suggest that this disease is not inherited in a simple manner, but an unspecified genetic abnormality involving the immune system is likely present.

This answer should not be considered medical advice...down arrowThis answer should not be considered medical advice and should not take the place of a doctor’s visit. Please see the bottom of the page for more information or visit our Terms and Conditions.up arrow

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Archived: March 20, 2014

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Read the Original Article: Understanding Scleroderma -- The Basics